HEP B CORE AB, TOT (REFL) 0002580

The hepatitis B core antibody is technically the anti-hepatitis B core antigen (anti-HBc). It is one of the first antibodies to appear after an acute hepatitis B infection and a more confirmatory test of Hepatitis B infection than the heptatitis B surface antigen (HBsAg) which is most often used for screening.

The hepatitis B surface antigen (HBsAg) is most frequently used to screen for the presence of this infection. It is the first detectable viral antigen to appear during infection. However, early in an infection, this antigen may not be present and it may be undetectable later in the infection as it is being cleared by the host. The infectious virion contains an inner “core particle” enclosing viral genome. The icosahedral core particle is known as hepatitis B core antigen, or HBcAg. During this ‘window’ in which the host remains infected but is successfully clearing the virus, IgM antibodies specific to the hepatitis B core antigen (anti-HBc IgM) may be the only serological evidence of disease. Therefore most hepatitis B diagnostic panels contain HBsAg and total anti-HBc (both IgM and IgG).